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Only Some of our References - All Research Exclusively from NCBI and PubMed.
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[2] Antille, C., Tran, C., Sorg, O. and Saurat, J. H. (2004) Penetration and metabolism of topical retinoids in ex vivo organ-cultured full-thickness human skin explants. Skin Pharmacol. Physiol. 17, 124-128.


[3] Shao Y, He T, Fisher GJ, Voorhees JJ, Quan T. Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo. Int J Cosmet Sci. 2017;39(1):56–65. doi:10.1111/ics.12348


[4] Lee, Woan-Ruoh & Shen, Shing-Chuan & Kuo-Hsien, Wang & Hu, Chung-Hong & Fang, Jia-You. (2003). Lasers and Microdermabrasion Enhance and Control Topical Delivery of Vitamin C. The Journal of investigative dermatology. 121. 1118-25. 10.1046/j.1523-1747.2003.12537.x.


[5] Lee, A.-R.C. & Tojo, Kakuji. (2001). An Experimental Approach to Study the Binding Properties of Vitamin E (.ALPHA.-Tocopherol) during Hairless Mouse Skin Permeation.. Chemical & pharmaceutical bulletin. 49. 659-63. 10.1248/cpb.49.659.


[6] Crisan D, Roman I, Crisan M, Scharffetter-Kochanek K, Badea R. The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach. Clin Cosmet Investig Dermatol. 2015;8:463–470. Published 2015 Sep 2. doi:10.2147/CCID.S84903


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[8] Hassanpour, S.E., Rostami, K., Azargashb, E., Saberi, K.M., Hamraz, S.H., Vajari, F.F., & Rouientan, A. (2019). The Effect of Topical Vitamin A and E on Ischemic Random Skin Flap Survival. World journal of plastic surgery.


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[17] Tokudome Y, Komi T, Omata A, Sekita M. A new strategy for the passive skin delivery of nanoparticulate, high molecular weight hyaluronic acid prepared by a polyion complex method. Sci Rep. 2018;8(1):2336. Published 2018 Feb 5. doi:10.1038/s41598-018-20805-3


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[26] Duarte, Tiago & Cooke, Marcus & Jones, George. (2008). Gene expression profiling reveals new protective roles for vitamin C in human skin cells. Free radical biology & medicine. 46. 78-87. 10.1016/j.freeradbiomed.2008.09.028.


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[28] Frank, C.B. (2004) Ligament structure, physiology and function. Journal of Musculoskeletal and Neuronal Interactions, 4, 199-201.


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[30] Pullar, J.M., Carr, A.C., & Vissers, M.C. (2017). The Roles of Vitamin C in Skin Health. Nutrients.


[31] Serre, C., Papillard, M., Chavassieux, P., Voegel, J., & Boivin, G. (1999). Influence of magnesium substitution on a collagen–apatite biomaterial on the production of a calcifying matrix by human osteoblasts. Journal of Biomedical Materials Research Part A, 42(4), 626-633.


[32] Chandrasekaran, N.C., Sanchez, W.Y., Mohammed, Y.H., Grice, J.E., Roberts, M.S., & Barnard, R.T. (2016). Permeation of topically applied Magnesium ions through human skin is facilitated by hair follicles. Magnesium research, 29 2, 35-42 .


[33] MacFarlane, A.J., Cogswell, M.E., de Jesus, J.M., Greene-Finestone, L.S., Klurfeld, D.M., Lynch, C.J., Regan, .K., & Yamini, .S. (2019). A report of activities related to the Dietary Reference Intakes from the Joint Canada-US Dietary Reference Intakes Working Group. American Journal of Clinical Nutrition, 109(2),


[34] Kafi, R., Kwak, H., Schumacher, W., Cho, S., Hanft, V., Hamilton, T., King, A., Neal, J., Varani, J., Fisher, G., Voorhees, J., & Kang, S. (2007). Improvement of Naturally Aged Skin With Vitamin A (Retinol). Archives of Dermatology, 143(5), 606-612.


[35] Min, Y., Niu, Z., Sun, T., Wang, Z., Jiao, P., Zi, B., Chen, P., Tian, D., & Liu, F. (2018). Vitamin E and vitamin C supplementation improves antioxidant status and immune function in oxidative-stressed breeder roosters by up-regulating expression of GSH-Px gene. Poultry Science, 97(4), 1238-1244.


[36] Kong, R., Cui, Y., Fisher, G., Wang, X., Chen, Y., Schneider, L., & Majmudar, G. (2016). A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin. Journal of Cosmetic Dermatology, 15(1), 49-57.


[37] Varani, J., Warner, R.L., Gharaee-Kermani, M., Phan, S.H., Kang, S., Chung, J.H., Wang, Z., Datta, S.C., Fisher, G.E., & Voorhees, J.H. (2000). Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. The Journal of investigative dermatology, 114 3, 480-6 .


[38] Romana-Souza, B., Silva-Xavier, W., & Monte-Alto-Costa, A. (2018). Topical retinol attenuates stress-induced ageing signs in human skin ex vivo, throughEGFR activation viaEGF, but notERK andAP-1 activation. Experimental dermatology.


[39] Berkers, T., Dijk, L.V., Absalah, S., Smeden, J.V., & Bouwstra, J.A. (2017). Topically applied fatty acids are elongated before incorporation in the stratum corneum lipid matrix in compromised skin. Experimental dermatology, 26 1, 36-43 .


[40] WRIGHT, S. (1991). Essential fatty acids and the skin. British Journal of Dermatology, 125(6),


[41] Dapic, I., Kobetic, R., Brkljacic, L., Kezic, S., & Jakasa, I. (2018). Quantification of free fatty acids in human stratum corneum using tandem mass spectrometry and surrogate analyte approach. Biomedical Chromatography, 32(2), n/a-n/a.


[42] McCusker, M., & Grant-Kels, J. (2010). Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids. Clinics in Dermatology, 28(4), 440-451.


[43] Cui, L., Jia, Y., Cheng, Z., Gao, Y., Zhang, G., Li, J., & He, C. (2016). Advancements in the maintenance of skin barrier/skin lipid composition and the involvement of metabolic enzymes. Journal of Cosmetic Dermatology, 15(4), 549-558.


[44] Kendall, A., Kiezel-Tsugunova, M., Brownbridge, L., Harwood, J., & Nicolaou, A. (2017). Lipid functions in skin: Differential effects of n-3 polyunsaturated fatty acids on cutaneous ceramides, in a human skin organ culture model. Biochimica et Biophysica Acta Biomembranes Or Bba Biomembranes, 1859(9), 1679-1689.


[45] Burnett, C., Fiume, M., Bergfeld, W., Belsito, D., Hill, R., Klaassen, C., Liebler, D., Marks, J., Shank, R., Slaga, T., Snyder, P., & Alan Andersen, F. (2017). Safety Assessment of Plant-Derived Fatty Acid Oils. International Journal of Toxicology, 36(3_suppl), 51S-129S.


[46] Arct, J., Chelkowska, M., Kasiura, K., & Pietrzykowski, P. (2002). The fatty acids as penetration enhancers of amino acids by ion pairing. International Journal of Cosmetic Science, 24(6),


[47] Dioguardi, F. (2008). Nutrition and skin. Collagen integrity: a dominant role for amino acids. Clinics in Dermatology, 26(6), 636-640.


[48] Gauza-Włodarczyk, M., Kubisz, L., & Włodarczyk, D. (2017). Amino acid composition in determination of collagen origin and assessment of physical factors effects. International Journal of Biological Macromolecules, 104, 987-991.


[49] Dioguardi, F. (2008). Nutrition and skin. Collagen integrity: a dominant role for amino acids. Clinics in Dermatology, 26(6), 636-640.


[50] DePhillipo NN, Aman ZS, Kennedy MI, Begley JP, Moatshe G, LaPrade RF. Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthop J Sports Med. 2018;6(10):2325967118804544. Published 2018 Oct 25. doi:10.1177/2325967118804544


[51] Lacroix, S., Bouez, C., Vidal, S., Cenizo, V., Reymermier, C., Justin, V., Vičanová, J., & Damour, O. (2006). Supplementation with a complex of active nutrients improved dermal and epidermal characteristics in skin equivalents generated from fibroblasts from young or aged donors. Biogerontology, 8(2), 97-109.


[52] Anderson, B. Nutrition and wound healing: the necessity of assessment. British Journal of Nursing 2005 14:Sup5, S30-S38


[53] Moores, J. (2013). Vitamin C: a wound healing perspective. British Journal of Community Nursing, 18(Sup12), S6-S11.


[54] Sinno, S., Lee, D., & Khachemoune, A. (2011). Vitamins and cutaneous wound healing. Journal of Wound Care, 20(6), 287-293.


[55] Mohammed, B., Fisher, B., Kraskauskas, D., Ward, S., Wayne, J., Brophy, D., Fowler, A., Yager, D., & Natarajan, R. (2016). Vitamin C promotes wound healing through novel pleiotropic mechanisms. International Wound Journal, 13(4), 572-584.


[56] Johnstone, C., Farley, A., & Hendry, C. (2005). The physiological basics of wound healing. Nursing Standard, 19(43), 59-65.


[57] Samarawickrama, C., Chew, S., & Watson, S. (2015). Retinoic acid and the ocular surface. Survey of Ophthalmology, 60(3), 183-195.


[58] Graves C, Saffle J, Cochran A. Actual burn nutrition care practices:an update. J Burn Care Res 2009;30:77-82.


[59] Hobson, R. (2016). Vitamin E and wound healing: an evidence‐based review. International Wound Journal, 13(3), 331-335.


[60] Silva, J., Burger, B., Kühl, C., Candreva, T., dos Anjos, M., & Rodrigues, H. (2018). Wound Healing and Omega-6 Fatty Acids: From Inflammation to Repair. Mediators of Inflammation, 2018, 17


[61] Ribeiro Barros Cardoso, C., Aparecida Souza, M., Amália Vieira Ferro, E., Favoreto, S., & Deolina Oliveira Pena, J. (2004). Influence of topical administration of n‐3 and n‐6 essential and n‐9 nonessential fatty acids on the healing of cutaneous wounds. Wound Repair and Regeneration, 12(2),


[62] Cardoso, C., Favoreto, S., Oliveira, L., Vancim, J., Barban, G., Ferraz, D., & Silva, J. (2011). Oleic acid modulation of the immune response in wound healing: A new approach for skin repair. Immunobiology, 216(3), 409-415.


[63] Tanvir, R., Javeed, A., & Rehman, Y. (2018). Fatty acids and their amide derivatives from endophytes: new therapeutic possibilities from a hidden source. FEMS Microbiology Letters, AdvanceArticle(12),


[64] Murillo, A., & Fernandez, M. (2016). Potential of Dietary Non-Provitamin A Carotenoids in the Prevention and Treatment of Diabetic Microvascular Complications. Advances in Nutrition, 7(1), 14-24.


[65] Ruffell, S., Müller, K., & McConkey, B. (2015). Comparative assessment of microalgal fatty acids as topical antibiotics. Journal of Applied Phycology, 28(3), 1695-1704.


[66] Jung, S., & Lee, S. (2016). The antibacterial effect of fatty acids on Helicobacter pylori infection. The Korean Journal of Internal Medicine, 31(1), 30-35.


[67] Desbois, A., Mearns-Spragg, A., & Smith, V. (2008). A Fatty Acid from the Diatom Phaeodactylum tricornutum is Antibacterial Against Diverse Bacteria Including Multi-resistant Staphylococcus aureus (MRSA). Marine Biotechnology, 11(1), 45-52.


[68] Hinton Jr, A., & Ingram, K. (2012). Influence of Ethylenediamine-N,N’-Discuccinic Acid (EDDS) Concentration on the Bactericidal Activity of Fatty Acids in Vitro*. Journal of Food Safety, 32(1), 102-107.


[69] “Microdermabrasion.” Microdermabrasion, American Academy of Dermatology, 2019, www.aad.org/public/diseases/cosmetic-treatments/microdermabrasion.