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Relief

The Science Behind

INTRODUCTION

Here you will find a brief overview of the science behind Biomechanic Labs  2-Step Pain Relief Kit with AMA formatted citations of supporting scientific evidence published on MEDLINE courtesey of the National Center of Biotechnology Information and PubMed – the same resources used by doctors and universities worldwide. We will cover the science of absorption and what makes Biomechanic Labs more effective in topical pain relief.  At the end, we will cover the additional benefits Biomechanic Labs may provide for you.

Our First Priority

ABSORPTION 

Permeation Through the Statum Corneum Depends on Lipophilicity and Molecular Weight

     The statum corneum is the top-most layer of skin. It is widely known from numerous studies that lipophicility (the ability of a chemical compound to dissolve in fats) and molecular weight play the primary role in absorption through the skin. Here are just a few studies if you are interested in learning in full depth about this relationship.

Cronin et al., 1999 [14]

Degim, 2006 [15]

Potts and Guy, 1992 [16]

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Biomechanic Labs Low Molecular Weight

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All Biomechanic Labs Ingredients Highly Liphilic

THE THREE ABSORPTION PATHWAYS

absorption pATHWAYS

Intercellular: pathway between cells

Intracellular: pathway through cells

Transappendageal: pathway through hair follicles and sweat glands

Up to 72 Hours of Relief

When applied correctly, Biomechanic Labs 2-Step Pain Relief Kitwill provide a full day of relief.

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Biomechanic Labs 100% all-natural anti-inflammatory scrub and a nano CBD topical gel

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Biomechanic Labs Nourishes Collagen

99.5% All-natural/organic

Because of high levels of absorption, all ingredients in Biomechanic Labs are 99.5% all-natural/organic from GMP certified manufacturers within the U.S. and .5% gelling agent used to make the gel itself. These ingredients are high in specially selected vitamins and fatty acids that reduce inflammation which is the root cause of pain and reduced mobility.

Nutrtition for Your Skin

Biomechanic Labs is specially formulated to include select nutrients.  With over 84 minerals, a variety of vitamins, fatty acids, minerals, antioxidants, and all 20 amino acids – we provide everything the body needs to create healthy skin cells.

Size Matters

Dalton 500 Rule

The barrier function of skin is principally attributed to the stratum corneum. Only small molecules, usually less than 500 Da, and lipophilic compounds can penetrate the skin barrier [17]

     A Dalton (abbreviated Da.) is a unit of mass widely used in physics and chemistry. You can think of it as a weight scale for an atom or molecule. There is an association between the size of an atom or molecule and its weight as well asorbability. For example an atom of helium-4 has a mass of 4.0026 Da.  Aspirin, C9H8O4, has an average mass of approximately 180.157.  So in general, the higher the weight of the atom/molecule the larger the size of the atom/molecule.

     The human skin is indeed an effective barrier but it cannot prevent smaller molecules to enter.  Somewhere around 500Dalton is the start of a rapid decline in skin ab-sorption due to molecular size. [9]

VISUAL REPRESENTATION OF MOLECULAR WEIGHT VS ABSORPTION

     Graph representing the relationship between the molecular weight of a compound and how well it absorbs into the skin (below).

ANALYSIS

HOW BIOMECHANIC LABS MATCHES UP

List of Nutrients in 2-Step Pain Relief Kit Under 500 Daltons

Vitamin B, Vitamin E, Lysine, Methionine, Cystine, Threonine, Isoleucine, Valine, Leucine, Histidine, Phenylalanine, Tyrosene, Aspartic Acid, Serine, Glutamine, Proline, Glycine, Alanine, Asparagine, Glutamic Acid, Arginine, Tryptophan.

Vitamin C, Palmitoleic Acid (16:1), Estearic Acid (18:0), Oleic Acid (18:1), Linoleic Acid (18:2,ω-6), Eicosanoic Acid (20:0), α-Linolenic Acid (18:3,ω-3), γ-Linolenic Acid (18:3,ω-6), Eicosenoic Acid (20:1), Docosanoic Acid (22:0)

Minerals: Magnesium, Phosphorus, Sodium, Calcium, Potassium

Vitamin A, Magnesium, Phosphorus, Potassium, Calcium, Carotene, Sodium, Manganese, Zinc, Copper, Glycerin, a-pinene, limonene, 1,8-cineole, cis-ocimene, trans-ocimene, 3-octanone, camphor, linalool, linalyl acetate, caryophyllene, terpinen-4-ol, lavendulyl acetate

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All ingredients in Biomechanic Labs 2-Step Pain Relief Kit Under 500 Daltons

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92% of Ingredients Under 100 Daltons

How we attack pain and inflammation

ACTIVE INGREDIENTS

List of Active Ingredients Proven to Reduce Inflammation and Pain with Supporting Citations from the National Center of Biotechnology Information

  • CBD [71] [72] [73]
  • Linalool [74] [75] [76]
  • Omega-3 Fatty Acids [77] [78] [79]
  • Vitamin E [80] [81] [82]
  • Vitamin A [83] [84] [85]
  • Vitamin C [86] [83]87] [88]
  • Magnesium [89] [90] [91] 
  • Caprylic Acid  [92] [93] [94]
  • Caproic Acid  [95] [96] [97]

Now let’s see how each of these active ingredients fight inflammation and pain in totally different ways. In medicine, these different ways are called pathways.  Pathways refer to a series of steps or interactions between molecules, cells, or tissues that lead to a specific biological response or outcome. These pathways are fundamental to understanding the mechanisms underlying various physiological processes, diseases, and therapeutic interventions. Here’s an example of a list of pathways for inflammation:

Inflammatory Signaling Pathways: These pathways regulate the production and release of inflammatory mediators, such as cytokines, chemokines, and prostaglandins, in response to tissue injury, infection, or other stimuli. Key pathways include:

  • NF-κB (Nuclear Factor-kappa B) pathway: Regulates the expression of genes involved in inflammation, immune responses, and cell survival.
  • MAPK (Mitogen-Activated Protein Kinase) pathway: Controls the activation of transcription factors and the production of inflammatory cytokines.
  • JAK-STAT (Janus Kinase-Signal Transducer and Activator of Transcription) pathway: Mediates the signaling of cytokines and growth factors involved in inflammation and immune

List of Pathways Each Active Ingredient in the 2-Step Pain Relief Kit Takes to Fight Inflammation and Pain

Pathways for Inflammation:

  1. Endocannabinoid System (ECS) Modulation
  2. Serotonin Receptor Activation 
  3. TRPV1 Receptor Modulation
  4. Terpene Activity 
  5. GABAergic System Modulation 
  6. Prostaglandin Production
  7. Gene Expression Regulation
  8. GLA Conversion 
  9. Inhibition of Inflammatory Mediators 
  10. Antioxidant Activity 
  11. Immune Modulation
  12. Regulation of Inflammatory Pathways
  13. Effects of caprylic acid and caproic acid 
  14. Various roles of amino acids in metabolism, neurotransmitter synthesis, and antioxidant defense

Total pathways for inflammation: 14

Pathways for Pain Inhibition:

  1. TRPM8 Receptor Activation 
  2. Calcium Channel Blockade 
  3. Terpene Activity 
  4. Endocannabinoid System
  5. Serotonin Receptor Activation
  6. Analgesic Effects 
  7. Potential effects of caprylic acid and caproic acid 

The ingredients analyzed encompass a diverse array of pathways aimed at combating inflammation and pain. Cannabidiol (CBD) operates through the endocannabinoid system, serotonin receptors, and TRPV1 receptors, while terpenes such as linalool and components like omega-3 fatty acids exert anti-inflammatory effects. Vitamin E contributes through antioxidant activity, alongside immune modulation facilitated by vitamins A and C. Magnesium regulates inflammatory pathways, and MCT oil’s caprylic and caproic acids offer additional avenues for pain relief. Moreover, amino acids participate in various metabolic, neurotransmitter synthesis, and antioxidant processes. Collectively, these ingredients engage in a multifaceted approach targeting diverse biological mechanisms to alleviate inflammation and pain, offering a holistic perspective on natural therapeutic interventions. Our active ingredients are Vitamin A, C, E, MCT Oil (found in coconut oil), Magnesium, These ingredients exert their effects through various mechanisms, including modulation of receptor activity, inhibition of inflammatory mediators, and regulation of gene expression, ultimately leading to pain relief and inflammation reduction.

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Proven Anti-Inflammatory and Pain Relieving Agents

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Pain Relieiving and Anti-Inflammatory Agents Work Synergistically Through Numerous Unique Pathways

BE READY FOR ANYTHING

From the beginning, Biomechanic Labs has been focused on outperforming OTC steroid filled creams by using a novel approach to successfully deliver superior results to you! We are innovative leaders with a passion for pain relief, and also a passion for needs like plantar faciitis. But at the end of the day, our biggest success is helping people get more people enjoyment out of living a better quality of life.

BIOMECHANIC LABS 2-STEP PAIN RELIEF KIT

  • LASTS 3.5-72 HOURS
  • ABSORBS & WORKS INSTANTLY
  • USED BY DOCTORS
  • TRIPLE EFFECT PAIN RELIEF

 

 $34.99

MEDLINE REFERENCES

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136519/
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https://www.ncbi.nlm.nih.gov/pubmed/14708614
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https://www.ncbi.nlm.nih.gov/pubmed/10839713

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